I don't think drilling one hole in the end and then tipping the boat to fill the sponson is going to work very well for the foam. What happens is the foam sets pretty fast and plugs the conduit, any foam poured after that just fills the cavity in front of the plug. When filling large side panel voids I drill pour holes (bigger holes) only as far apart as 1 cubic foot of space will allow, I also drill relief/viewing holes (smaller holes) much closer together to make sure I get the coverage and volume I need.
A six foot side panel that is 20 inches tall and 4 inches deep has a volume of 3.3 cubic feet. ! would drill 4 2" pour holes and seven or eight relief holes (you need to give the displaced air somewhere to go). I would mix and pour 8 ozs of foam at a time as this is about as much as I can handle by my self before it blows.
So, for your sponsons, I would think you will need at least three pour holes and several more relief holes between them to get full coverage.
However, there is an alternative. build the sponsons, pour the foam in them, and then weld them to the boat. You will loose a little due to the heat of welding, but not much I wouldn't think, and you can use heat blocking pasts to keep the affected area down to a minimum. I have never welded over foam so i don't know how it would work, try a test first, but i think that is going to be the best solution if you want foam.
That's what I would do anyway.
In fact, you don't really need the foam if your welding is good, an airtight chamber is good enough. you can test it with dry Nitrogen before you seal it up. I would put a plug in the rear tho for those times you puncture the sponson and need to drain it thoroughly to make a repair. I would use a brass plug and solder it in.