Spread bay powder on teh ground and pull the trailer through it. Look at the marks in teh powder, you should see full tread on both tires. If not, your tires are either over inflated or underinflated.
Measure the tires in 4 positions, North, South, West and East. Best to put the tape on one tire and measure to the other. Front and back should be the same, top and bottom should be the same. If either set of numbers differs, you found your problem.
Bearings WILL play a huge roll in tire longevity, so will springs.
By the way, Hunter makes the best tire balance equipment on the market. Take your tires to a tire shop that has a Hunter Road Force balancer and have your tires and wheels checked. One or both of your wheels could be bend and you will never know it. The Hunter will check the tire to the wheel, it will recommend the best tire position in relation to the wheel. Believe it or not, tires and wheels are not perfectly round, they are more egg shaped. The balancer will recommend the best tire position to minimize the egg shape and turn it into a round rolling mass.
It could also be that your trailer is under loaded for the springs you have.
Post up what you find out.
One last thing, are you using trailer tires and not passenger or light truck tires?
and are these bias ply's or radials?